Genetic characterization of TET1, TET2, and TET3 alterations in myeloid

Disease alleles that activate signal trans-duction are common in myeloid malignan-cies; however, there are additional uniden-tified mutations that contribute to myeloid transformation. Based on the recent iden-tification of TET2 mutations, we evalu-ated the mutational status of TET1, TET2, and TET3 in myeloproliferative neoplasms (MPNs), chronic myelomonocytic leuke-mia (CMML), and acute myeloid leukemia (AML). Sequencing of TET2 in 408 paired tumor/normal samples distinguished be-tween 68 somatic mutations and 6 novel single nucleotide polymorphisms and identified TET2 mutations in MPN (27 o