Development of the mammary gland during puberty, preg-nancy, and lactation is controlled by steroid and peptide hormones and growth factors. To determine the role of the insulin-like growth factors (IGFs) in this process we devel-oped a transgenic model using the whey acidic protein (WAP) gene to direct expression of rat IGF-I and human IGF binding protein-3 (IGFBP-3) to mammary tissue dur-ing late pregnancy and throughout lactation. High levels of expression of transgenic IGF-I and IGFBP-3 were seen in lobular-alveolar cells by in situ hybridization. There was no obvious effect on mammary development dur-ing pregnancy and lactation; indeed, mothers were capable of nursing their pups normally and the only structural dif-ference seen in the ...
The mouse mammary epithelial cell line HC11 upregulates the synthesis of beta-casein (a differentiat...
Insulin-like growth factors (IGFs) play an important role in mammary gland development and their eff...
The heterozygous prolactin (PRL) receptor (PRLR+/−) mouse fails to develop a fully functional mammar...
We have previously demonstrated that IGFBP-5 production by mammary epithelial cells increases dramat...
We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mamma...
Background: Insulin like growth factors (IGFs) and their binding proteins (IGFBPs) are secreted pept...
We have used quantitative RT-PCR to analyse the mRNA expression profile of the major components of t...
We have previously demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) is upreg...
BACKGROUND: Insulin like growth factors (IGFs) and their binding proteins (IGFBPs) are secreted pept...
<div><p>Background</p><p>Insulin like growth factors (IGFs) and their binding proteins (IGFBPs) are ...
Insulin-like growth factor-binding protein 5 (IGFBP-5) mediates involution of the mammary gland. The...
Mammary gland development is dependent upon insulin-like growth factors (IGFs) as survival factors. ...
Postnatal development of the mammary gland requires interactions between the epithelial and stromal ...
We have studied the physiology and tissue expression of IGF-I and IGF-BP3 in pregnant and lactating ...
The somatotropic axis is one of the major hormonal systems regulating growth, development, and metab...
The mouse mammary epithelial cell line HC11 upregulates the synthesis of beta-casein (a differentiat...
Insulin-like growth factors (IGFs) play an important role in mammary gland development and their eff...
The heterozygous prolactin (PRL) receptor (PRLR+/−) mouse fails to develop a fully functional mammar...
We have previously demonstrated that IGFBP-5 production by mammary epithelial cells increases dramat...
We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mamma...
Background: Insulin like growth factors (IGFs) and their binding proteins (IGFBPs) are secreted pept...
We have used quantitative RT-PCR to analyse the mRNA expression profile of the major components of t...
We have previously demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) is upreg...
BACKGROUND: Insulin like growth factors (IGFs) and their binding proteins (IGFBPs) are secreted pept...
<div><p>Background</p><p>Insulin like growth factors (IGFs) and their binding proteins (IGFBPs) are ...
Insulin-like growth factor-binding protein 5 (IGFBP-5) mediates involution of the mammary gland. The...
Mammary gland development is dependent upon insulin-like growth factors (IGFs) as survival factors. ...
Postnatal development of the mammary gland requires interactions between the epithelial and stromal ...
We have studied the physiology and tissue expression of IGF-I and IGF-BP3 in pregnant and lactating ...
The somatotropic axis is one of the major hormonal systems regulating growth, development, and metab...
The mouse mammary epithelial cell line HC11 upregulates the synthesis of beta-casein (a differentiat...
Insulin-like growth factors (IGFs) play an important role in mammary gland development and their eff...
The heterozygous prolactin (PRL) receptor (PRLR+/−) mouse fails to develop a fully functional mammar...