SUMMARY

ies, after purification in vivo from in-duced hepatomas in rats, localized in the total hepatic region (liver with hep-atoma) of hepatoma-hearing rats to an extent as high as 60 percent of the in-jected dose. The localized antibodies were shared almost equally by hepato-ma and non-neoplastic portions. When the purified antibodies were pas-sively transferred through normal rats, cross-localizing antibodies were ab-sorhed from the circulation. Anti-bodies that remained in the serum, when assayed in hepatoma-hearing rats, preferentially localized in discrete hepatomas and localized to as high as 40 percent of the injected dose in the total hepatic region. When assayed in normal rats, the same preparation localized at the 4 percent level in liver. Antihepatoma antibodies, when puri-fied in vivo from normal liver of normal rats and assayed in hepatoma-bearing rats, preferentially localized in the non-neoplastic portions of the hepatic region.-J. Nat. Cancer Inst. 27: 1107