Mutation in FAM134B causing

severe hereditary sensory neuropathy The hereditary sensory and autonomic neuropathies (HSAN) are rare inherited neuropathies presenting with sensory loss and complications, including ulcers, infec-tions, osteomyelitis and amputations. Usually, sensory symptoms predominate although motor involvement can occur. Autonomic features may be minimal (then hereditary sensory neuropathy, HSN, is preferred). HSAN has been classified into five subtypes depending on clinical presentation.1 Hereditary sensory and autonomic neuropathy II (HSANII or HSNII) is an earl