Add to ORKGWnt/-catenin signaling is central to bone development and homeostasis in adult-hood and its deregulation is associated with bone pathologies. Dickkopf-1 (DKK1), a soluble inhibitor of Wnt/-catenin signal-ing required for embryonic head develop-ment, regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow. LRP5 mutations causing high bone mass syndromes dis-rupt DKK1-mediated regulation of LRP5. Forced overexpression of Dkk1 in osteo-blasts causes osteopenia, disruption of the hematopoietic stem cell (HSC) niche, and defects in HSC function. Dkk1 als
Copyright © 2013 Nicola Giuliani et al.This is an open access article distributed under the Creative...
Mesenchymal stem cells (MSCs) are a group of multipotent cells with key properties of multi-lineage ...
Claudins (Cldns), a family of 27 transmembrane proteins, represent major components of tight junctio...
PURPOSE OF REVIEW: This review summarizes recent findings concerning the genomic variations of the l...
Background: Bone remodeling is a lifelong process due to the balanced activity of osteoclasts (OCs),...
PURPOSE OF REVIEW:We reviewed the current literature on the roles of the Wnt antagonists sclerostin ...
During vertebrate neurulation, cranial neural crest cells (CNCCs) undergo epithelial to mes-enchymal...
The last decade has seen an exponential increase in our understanding of osteocytes function and bio...
This article is not available through ChesterRep.This article discusses Dickkopf-1 (Dkk-1), which is...
Abstract: Recent experiments have explored the impact of Wnt/β-catenin signaling and Substance P (SP...
Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteocl...
Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was f...
SummaryWnt proteins (Wnts) are palmitoylated and glycosylated ligands that play a central role in th...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusi...
Copyright © 2013 Nicola Giuliani et al.This is an open access article distributed under the Creative...
Mesenchymal stem cells (MSCs) are a group of multipotent cells with key properties of multi-lineage ...
Claudins (Cldns), a family of 27 transmembrane proteins, represent major components of tight junctio...
PURPOSE OF REVIEW: This review summarizes recent findings concerning the genomic variations of the l...
Background: Bone remodeling is a lifelong process due to the balanced activity of osteoclasts (OCs),...
PURPOSE OF REVIEW:We reviewed the current literature on the roles of the Wnt antagonists sclerostin ...
During vertebrate neurulation, cranial neural crest cells (CNCCs) undergo epithelial to mes-enchymal...
The last decade has seen an exponential increase in our understanding of osteocytes function and bio...
This article is not available through ChesterRep.This article discusses Dickkopf-1 (Dkk-1), which is...
Abstract: Recent experiments have explored the impact of Wnt/β-catenin signaling and Substance P (SP...
Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteocl...
Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was f...
SummaryWnt proteins (Wnts) are palmitoylated and glycosylated ligands that play a central role in th...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusi...
Copyright © 2013 Nicola Giuliani et al.This is an open access article distributed under the Creative...
Mesenchymal stem cells (MSCs) are a group of multipotent cells with key properties of multi-lineage ...
Claudins (Cldns), a family of 27 transmembrane proteins, represent major components of tight junctio...