Circulating, but not Local Lung, IL-5 Is Required for the Development of

IL-5 is induced locally in the lung and systemically in the circulation during allergic airways eosinophilic inflamma-tion both in humans and experimental animals. However, the precise role of local and systemic IL-5 in the develop-ment of allergic airways eosinophilia remains to be eluci-dated. In our current study, we demonstrate that compared with their IL-