The biological potential of hepatic foci and tumors induced by peroxisome proliferators such as Wy-14,643 has been poorly characterized. In this study, male F-344 rats (n = 20/group/time point) were fed Wy-14,643 (0.1%) for 22, 37 or 52 weeks ('W-22', 'W-37 ' or 'W-52 ' respectively). At each time point some rats were killed and additional Wy-14,643-fed rats were switched to basal diet (Wy-14,643/'stopped') for up to 104 weeks (referred to as 'W-22/S', ' W-37/S ' and 'W-52/S'). Homogeneous basophilic foci, but not clear cell foci, increased in number and size in W-37 and W-52 rats. In W-37/S rats, clear cell foci replaced basophilic foci as the most frequent phenotype. I...
A series of experiments was performed to investigate the effect of different types of cell prolifera...
Peroxisome proliferators constitute an important group of xenobiotics with therapeutic, societal, an...
Wy-14,643 (WY) is a hypolipidemic drug that induces hepatic peroxisome proliferation and tumors in r...
We investigated the mechanism of the hepatocarcinogenic action of nafenopin (NAF), a nongenotoxic pe...
Background: Liver preneoplasia development in rats can be mimicked by an initiation-promotion model ...
Peroxisome proliferators (PPs) cause proliferation of peroxisomes and hepatocarcinogenesis in rodent...
In compensatory hyperplasia after partial hepatectomy or liver cell injury, hepatocyte proliferation...
The purpose of the workshop "Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard ...
LY171883 was shown to increase the incidence of hepatocel-lular carcinomas and other proliferative l...
1To whom correspondence should be addressed Peroxisome proliferators (PP) are known hepatocarcino-ge...
Three rat liver foci bioassays have been compared with respect to their sensitivity by the histochem...
International audiencePeroxisome proliferators (PPs) are a class of rodent nongenotoxic hepatocarcin...
The peroxisome proliferators represent an important group of hepatic carcinogens in rodents that act...
Certain lipid-regulating agents induce hepatomegaly, hepatic peroxisome proliferation and hepatocarc...
An investigation into the early cell biology changes in response to non-genotoxic carcinogens was ca...
A series of experiments was performed to investigate the effect of different types of cell prolifera...
Peroxisome proliferators constitute an important group of xenobiotics with therapeutic, societal, an...
Wy-14,643 (WY) is a hypolipidemic drug that induces hepatic peroxisome proliferation and tumors in r...
We investigated the mechanism of the hepatocarcinogenic action of nafenopin (NAF), a nongenotoxic pe...
Background: Liver preneoplasia development in rats can be mimicked by an initiation-promotion model ...
Peroxisome proliferators (PPs) cause proliferation of peroxisomes and hepatocarcinogenesis in rodent...
In compensatory hyperplasia after partial hepatectomy or liver cell injury, hepatocyte proliferation...
The purpose of the workshop "Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard ...
LY171883 was shown to increase the incidence of hepatocel-lular carcinomas and other proliferative l...
1To whom correspondence should be addressed Peroxisome proliferators (PP) are known hepatocarcino-ge...
Three rat liver foci bioassays have been compared with respect to their sensitivity by the histochem...
International audiencePeroxisome proliferators (PPs) are a class of rodent nongenotoxic hepatocarcin...
The peroxisome proliferators represent an important group of hepatic carcinogens in rodents that act...
Certain lipid-regulating agents induce hepatomegaly, hepatic peroxisome proliferation and hepatocarc...
An investigation into the early cell biology changes in response to non-genotoxic carcinogens was ca...
A series of experiments was performed to investigate the effect of different types of cell prolifera...
Peroxisome proliferators constitute an important group of xenobiotics with therapeutic, societal, an...
Wy-14,643 (WY) is a hypolipidemic drug that induces hepatic peroxisome proliferation and tumors in r...