CD94/NKG2C natural killer (NK) cells are increased in healthy individuals infected with human cytomegalovirus (HCMV), suggesting that HCMV infection may shape the NK cell receptor repertoire. To address this question, we analyzed the distribution of NK cell subsets in periph-eral blood lymphocytes (PBLs) cocul-tured with HCMV-infected fibroblasts. A substantial increase of NK cells was de-tected by day 10 in samples from a group of HCMV donors, and CD94/NKG2C cells outnumbered the CD94/NKG2A subset. Fibroblast infection was required to induce the preferential expansion of CD94/NKG2C NK cells that was compa-rable with allogeneic or autologous fibro-blasts, and different virus strains. A CD94-specific monoclonal antibody (mAb) abrogated th...
Natural killer (NK) cells are important effectors of innate immunity that play a critical role in th...
Human cytomegalovirus (HCMV) has been closely associated with the human race across evolutionary tim...
Expansion of natural killer (NK) cells expressing NKG2C occurs following human cytomegalovirus (HCMV...
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a ma...
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a ma...
Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system. These include the ...
Immune responses of Natural Killer (NK) cell are controlled by the balance between activating and in...
This is the author accepted manuscript. The final version is available from the American Society for...
Human cytomegalovirus (HCMV) infection induces a persistent reconfiguration of the NK cell compartm...
CMV induces the expansion of a unique subset of human NK cells expressing high levels of the activat...
Human cytomegalovirus (HCMV) exploits a range of strategies to evade and modulate the immune respons...
Introduction: Dysregulated NK cell-mediated immune responses contribute to tumor evasion in chronic ...
International audienceHuman natural killer (NK) cells are functionally regulated by killer cell immu...
Natural Killer (NK) cell function is regulated by an array of inhibitory and activating surface rece...
Human cytomegalovirus (HCMV) infection induces persistent changes in the host immune system, namely ...
Natural killer (NK) cells are important effectors of innate immunity that play a critical role in th...
Human cytomegalovirus (HCMV) has been closely associated with the human race across evolutionary tim...
Expansion of natural killer (NK) cells expressing NKG2C occurs following human cytomegalovirus (HCMV...
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a ma...
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a ma...
Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system. These include the ...
Immune responses of Natural Killer (NK) cell are controlled by the balance between activating and in...
This is the author accepted manuscript. The final version is available from the American Society for...
Human cytomegalovirus (HCMV) infection induces a persistent reconfiguration of the NK cell compartm...
CMV induces the expansion of a unique subset of human NK cells expressing high levels of the activat...
Human cytomegalovirus (HCMV) exploits a range of strategies to evade and modulate the immune respons...
Introduction: Dysregulated NK cell-mediated immune responses contribute to tumor evasion in chronic ...
International audienceHuman natural killer (NK) cells are functionally regulated by killer cell immu...
Natural Killer (NK) cell function is regulated by an array of inhibitory and activating surface rece...
Human cytomegalovirus (HCMV) infection induces persistent changes in the host immune system, namely ...
Natural killer (NK) cells are important effectors of innate immunity that play a critical role in th...
Human cytomegalovirus (HCMV) has been closely associated with the human race across evolutionary tim...
Expansion of natural killer (NK) cells expressing NKG2C occurs following human cytomegalovirus (HCMV...