Correlation of repolarization of ventricular monophasic action potential with ECG in the murine heart

Correlation of repolarization of ventricular monophasic action potential with ECG in the murine heart. Am J Physiol Heart Circ Physiol 283: H372–H381, 2002;10.1152/ajpheart. 01091.2001.—Transgenic mice have become important ex-perimental models in the investigation of mechanisms caus-ing cardiac arrhythmias because of the ability to create strains with alterations in repolarizing membrane currents. It is important to relate alterations in membrane currents in cells to their phenotypic expression on the electrocardiogram (ECG). The murine ECG, however, has unusual characteris-tics that make interpretation of the phenotypic expression of changes in ventricular repolarization uncertain. The major deflection representing the QRS (referred to as “a”) is often followed by a secondary slower deflection (“b”) and sometimes a subtle third deflection (“c”). To determine whether th