THE RELATIONSHIP BETWEEN ASYMPTOMATIC HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND THE PREVALENCE AND SEVERITY OF ANEMIA IN PREGNANT MALAWIAN WOMEN

Abstract. The relationship between asymptomatic human immunodeficiency virus (HIV) infection and blood he-moglobin (Hb) concentration was examined in anemic pregnant women from a population with high prevalence of both anemia (60%) and HIV seropositivity (30%). Sera from 155 pregnant women with Hb levels, 10.5 g/dL were tested for HIV status, C-reactive protein (CRP), vitamin B12, retinol, and folate levels. The observed prevalence of HIV seropositivity in the group of women with anemia was 47.1 % (95 % confidence interval 5 39.2–55.0%). This is significantly higher than the HIV prevalence in the whole population (30.1%; P, 0.001). Median Hb values in HIV-seropositive and-seronegative women with anemia were 8.40 g/dL and 8.95 g/dL, respectively. Serum retinol, vitamin B12, and folate levels were not significantly different in the HIV-seropositive and-seronegative groups. In women who were HIV-seropositive with normal levels of CRP, a median decrease in Hb of 0.4g/dL was observed. For those with serum CRP levels. 25 mg/l, the median decrease in Hb was 0.7 g/dL. Results indicate that asymp-tomatic HIV infection is associated with increased prevalence and severity of anemia in pregnancy in this population. The World Health Organization estimates that at least 50% of pregnant women in Africa are anemic.1 In sub-Saharan Africa, the prevalence rates reported are between 58 % and 75%.1–5 A survey of antenatal clinic attenders at the Quee