Topics
lithiumChemical substance
TMEDAChemical substance
heterocycleChemical compound
hygroscopicDisease
transmetalationDisease
Abstract: Several unsymmetrical heterobiaryls have been synthesized through palladium-catalyzed cross-coupling reactions of lithium triorganozincates. The latter have been prepared by deprotonative lithiation followed by transmetalation using non hygroscopic ZnCl2·TMEDA (1/3 equiv). Key words: cross-coupling, heterocycle, metalation, palladium, zinc The importance of heterobiaryls in natural products and pharmaceutical intermediates, and their unique properties have stimulated tremendous efforts for the development of synthetic methods in the area of aryl-aryl bond formation.
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
International audienceSeveral unsymmetrical heterobiaryls have been synthesized through palladium-ca...
The cross-coupling of metallated heteroaromatic species with aryl and heteroaryl halides is a powerf...
The cross-coupling of metallated heteroaromatic species with aryl and heteroaryl halides is a powerf...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the...
Chapter 1. Highly active and efficient catalyst systems derived from palladium precatalysts and mono...
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the...
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the...
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the...
Heterobiaryls composed of pyridine and diazine rings are key components of pharmaceuticals and are o...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
International audienceSeveral unsymmetrical heterobiaryls have been synthesized through palladium-ca...
The cross-coupling of metallated heteroaromatic species with aryl and heteroaryl halides is a powerf...
The cross-coupling of metallated heteroaromatic species with aryl and heteroaryl halides is a powerf...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the...
Chapter 1. Highly active and efficient catalyst systems derived from palladium precatalysts and mono...
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the...
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the...
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the...
Heterobiaryls composed of pyridine and diazine rings are key components of pharmaceuticals and are o...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithiu...
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