Anti-human immunodeficiency virus type 1 activities of U-90152 and U-75875 in human brain cell cultures. Antimicrob. Agents Chemother

the protease inhibitor U-75875 were compared in two culture models of human immunodeficiency virus type 1 brain infection. In a model involving acutely infected microglial cells, U-90152 was the most active, whereas in a model using chronically infected promonocytes, U-75875 was the most active. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system is a frequent and often serious complication of AIDS (19). Treatment with 3'-azido-2',3'-dideoxythymidine (zidovudine) has been shown to reverse certain HIV-associated neurological abnormalities (7, 20, 22), and a reduced incidence of AIDS dementia complex has been attributed to the widespread use of this nucleoside analog reverse transcriptase (RT) inhibitor (17). Nevertheless, the neurological improvement following zidovudine therapy may be short-lived (18). Thus, the search for alternative therapies of HIV-1-related brain disease remains a priority. Little information is available on the antiviral properties o