Troponin T and N-Terminal Pro-B–Type Natriuretic Peptide: A Biomarker Approach to Predict Heart Failure Risk: The Atherosclerosis Risk in Communities Study

eases, heart failure (HF) is projected to have the largest increases in incidence over the coming decades; there-fore, improving HF prediction is of significant value. We evaluatedwhether cardiac troponin T (cTnT)mea-suredwith a high-sensitivity assay andN-terminal pro-B–type natriuretic peptide (NT-proBNP), biomarkers strongly associated with incident HF, improve HF risk prediction in the Atherosclerosis Risk in Communities (ARIC) study. METHODS: Using sex-specific models, we added cTnT and NT-proBNP to age and race (“laboratory report” model) and to the ARIC HFmodel (includes age, race, systolic blood pressure, antihypertensive medication use, current/former smoking, diabetes, body mass index, prevalent coronary heart disease, and hear