Add to ORKGBackground: The secreted protease inhibitor cystatin C is internalized into cancer cells. Results: Cystatin variants with altered uptake characteristics were identified, and shown to differently inhibit intracellular cathepsin B and legumain activities. Conclusion: The internalization process, an
Cysteine cathepsins are proteases that, in addition to their important physiological functions, have...
Background High activity of cysteine proteases such as legumain and the cathepsins h...
Cystatins are a family of intracellular and extracellular protease inhibitors that inhibit cysteine ...
To elucidate the molecular requirements for cancer cell internalization of the extracellular cystein...
Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal pe...
The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhi...
The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhi...
Copyright © 2013 Lauren Deady, James L. Cox. This is an open access article distributed under the Cr...
Some secreted cysteine protease inhibitors of the cystatin family appear to affect intracellular pro...
Some secreted cysteine protease inhibitors of the cystatin family appear to affect intracellular pro...
Cystatins are present in mammals, birds, fish, insects, plants, fungi and protozoa and constitute a ...
Background: Metastasis is the cause of most cancer related morbidity. A naturally occurring cysteine...
Cystatins are a family of naturally occurring cysteine protease inhibitors, yet the target proteases...
Cystatins are a family of naturally occurring cysteine protease inhibitors, yet the target proteases...
Background: High activity of cysteine proteases such as legumain and the cathepsins have been shown ...
Cysteine cathepsins are proteases that, in addition to their important physiological functions, have...
Background High activity of cysteine proteases such as legumain and the cathepsins h...
Cystatins are a family of intracellular and extracellular protease inhibitors that inhibit cysteine ...
To elucidate the molecular requirements for cancer cell internalization of the extracellular cystein...
Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal pe...
The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhi...
The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhi...
Copyright © 2013 Lauren Deady, James L. Cox. This is an open access article distributed under the Cr...
Some secreted cysteine protease inhibitors of the cystatin family appear to affect intracellular pro...
Some secreted cysteine protease inhibitors of the cystatin family appear to affect intracellular pro...
Cystatins are present in mammals, birds, fish, insects, plants, fungi and protozoa and constitute a ...
Background: Metastasis is the cause of most cancer related morbidity. A naturally occurring cysteine...
Cystatins are a family of naturally occurring cysteine protease inhibitors, yet the target proteases...
Cystatins are a family of naturally occurring cysteine protease inhibitors, yet the target proteases...
Background: High activity of cysteine proteases such as legumain and the cathepsins have been shown ...
Cysteine cathepsins are proteases that, in addition to their important physiological functions, have...
Background High activity of cysteine proteases such as legumain and the cathepsins h...
Cystatins are a family of intracellular and extracellular protease inhibitors that inhibit cysteine ...