THE EFFECT OF CERTAIN ANTACIDS IN MAN MEASURED BY A SIMPLIFIED METHOD FOR THE CONTINUOUS RECORDING OF GASTRIC pH*

IN a previous communication * we described a method for the continuous recording of gastric pH in man. At that time we were of the opinion that colloidal aluminum hydroxide t in 30 c.c. dosage made up to 200 c.c. with water, or 200 c.c. of milk alone, fulfilled the physiological criteria of an ideal antacid. It was also noted that the use of calcium carbonate or of mag-nesium salts caused.a great initial rise in pH but that their buffering effect was of short duration. In the present study we have extended our observations on antacids with the use of an improved method for the continuous recording of gastric pH. In the procedure as originally described a tube at least 5/16ths of an inch in diameter containing a glass electrode and accessory tubes was introduced into the stomach. It was necessary that the patient retain the tube during the entire period of observation. Another disadvantage was that this arrange-ment required frequent recementing of the glass electrode at the bottom of the stomach tube to avoid electrical leakage