aureus and Pseudomonas aeruginosa in vivo

Curcumin as a natural yellow pigment and a nontoxic, bioactive agent of turmeric separated from the root of Curcumin Longa has been uti-lized in traditional medicine. Besides, it has been observed that curcumin as a strong antibacterial drug is authenticated to inhibit the growth of sev-eral bacteria including Staphylococcus aureus and Pseudomonas aeruginosa is well-known as it a good candidate for treating inflammatory diseases (1, 2) The ability of this drug in skin wound heal-ing has been demonstrated on the other hand. In order to enhance wound healing, curcumin can increase biosynthesis of extracellular matrix pro-teins such as collagen (3, 4). Chitosan is a linear polysaccharide derived from crustacean shells and fungi cell walls. It has been used as a biocompatible and safe material in drug delivery systems (5-7). It has been recently used in bandages and other haemostatic agents (8, 9). In addition, chitosan due to the ability of preventing the wound from being infected and dehydrated can optimize suitable conditions for healing (10). It has also been utilized as an antimi-crobial agent that prevents the spread of infections into surrounding area (11, 12). Many studies have Iran J Biotech. 2014 November;12(3): e1012. DOI:10.15171/ijb.101