Review Article Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia

B-lymphocyte development in the bone marrow is controlled by the coordinated action of transcription factors creating regulatory networks ensuring activation of the B-lymphoid program and silencing of alternative cell fates. This process is tightly connected to malignant transfor-mation because B-lineage acute lympho-blastic leukemiacellsdisplayapronounced block in differentiation resulting in the expansion of immature progenitor cells. Over the last few years, high-resolution analysis of genetic changes in leukemia has revealed that several key regulators of normal B-cell development, includin