Add to ORKGstaining intensely, and gene amplification was defined as more than six gene copies per nucleus or a HER2/CEP17 ratio greater than 2.2. Equivocal results are defined as tissues with an IHC score of 2+ (complete but weak or weak to moderate cell membrane staining in>10 % of cells), 4.0–6.0 HER2 gene copies per nucleus determined by FISH, or a HER2/CEP17 ratio of 1.8–2.2 determined by FISH. The ASCO/CAP guidelines recommend that equivocal IHC samples be reassessed using a validated assay for HER2 gene amplifica-tion and that equivocal FISH samples have additional nuclei counted or be reteste
Aims A few reports have assessed HER2 status in breast cancer by both dual-probe fluorescence in sit...
<p>ER+/HER2- samples with systemic relapse events were probed for the amplification of 8p11.2, 17q22...
BACKGROUND: The primary objectives of this study on carcinomas with equivocal HER2 expression were ...
staining intensely, and gene amplification was defined as more than six gene copies per nucleus or a...
textabstractAims: Equivocal human epidermal growth factor receptor 2 protein (HER2) (2+) immunohisto...
A new method that simplifies the evaluation of the traditional HER2 fluorescence in situ hybridizati...
<p>Cases with copy number increases showed strong positive for EGFR (A), CCNE1 (B) and HER2 (C). A c...
<p>HER2 IHC and <i>Her2</i> FISH testing results by the ToGA surgical specimen and ToGA biopsy scori...
<p>FISH to determine EGFR and MYC copy number. Gene specific probes are labeled red (EGFR and MYC) w...
To our knowledge, there are no universally accepted, evidence-based guidelines for how to resolve th...
To retrospectively evaluate the HER2 status of 1 501 invasive breast cancer (IBC) by immunohistochem...
In this study the detection of HER2 gene amplification was evaluated using Fluorescence In Situ Hybr...
ASCO and the College of American Pathologists (ASCO-CAP) recently recommended further changes to the...
AbstractIt has been proven that chromosome 17 centromere (CEP17) amplification causes misleading hum...
HER2 may be a relevant biomarker in Barrett's cancer. We compared three HER2 laboratory methods,...
Aims A few reports have assessed HER2 status in breast cancer by both dual-probe fluorescence in sit...
<p>ER+/HER2- samples with systemic relapse events were probed for the amplification of 8p11.2, 17q22...
BACKGROUND: The primary objectives of this study on carcinomas with equivocal HER2 expression were ...
staining intensely, and gene amplification was defined as more than six gene copies per nucleus or a...
textabstractAims: Equivocal human epidermal growth factor receptor 2 protein (HER2) (2+) immunohisto...
A new method that simplifies the evaluation of the traditional HER2 fluorescence in situ hybridizati...
<p>Cases with copy number increases showed strong positive for EGFR (A), CCNE1 (B) and HER2 (C). A c...
<p>HER2 IHC and <i>Her2</i> FISH testing results by the ToGA surgical specimen and ToGA biopsy scori...
<p>FISH to determine EGFR and MYC copy number. Gene specific probes are labeled red (EGFR and MYC) w...
To our knowledge, there are no universally accepted, evidence-based guidelines for how to resolve th...
To retrospectively evaluate the HER2 status of 1 501 invasive breast cancer (IBC) by immunohistochem...
In this study the detection of HER2 gene amplification was evaluated using Fluorescence In Situ Hybr...
ASCO and the College of American Pathologists (ASCO-CAP) recently recommended further changes to the...
AbstractIt has been proven that chromosome 17 centromere (CEP17) amplification causes misleading hum...
HER2 may be a relevant biomarker in Barrett's cancer. We compared three HER2 laboratory methods,...
Aims A few reports have assessed HER2 status in breast cancer by both dual-probe fluorescence in sit...
<p>ER+/HER2- samples with systemic relapse events were probed for the amplification of 8p11.2, 17q22...
BACKGROUND: The primary objectives of this study on carcinomas with equivocal HER2 expression were ...