clinical, and immunological studies on the products of human plasma fractionation. XIII. Separation and concentration of isohemagglutinins from group-specific human plasma

The object of the series of investigations here-with reported has been to determine how blood plasma, fractionated into its component parts, may be used with the maximum effect in the treatment of clinical conditions. Extensive ex-perience has demonstrated that plasma is of unquestioned value in the treatment of shock, burns, and diseases in which there has been depletion of one or another of the components of plasma. Moreover, either pooled or convales-cent plasma has been injected in man because of either proven or implied effectiveness in the prophylaxis or treatment of certain infectious diseases. The constituents of plasma are not all equally effective in the treatment of diverse conditions, however. Therefore, the utilization of the whole plasma in therapy may often prove both less effective and less economical than the use of parts thereof. In the treatment of infectious disease, for example, such antibodies as may be present in blood constitute only a small fraction of the plasma globulins. The rest of the plasma has little proven value in the prevention or I This work was originally supported by grants from the Rockefeller Foundation and from funds of Harvard Uni-versity. It was aided early in 1941 by grants from th