49www.fmc.viamedica.pl

The effect of low birth weight on endothelial dysfunction in young adults: a retrospective cohort study Aim. To investigate the effect of low birth weight (LBW) on endothelial function, and to determine the role of plasma adiponectin in endothelial dysfunction by conducting flow mediated brachial artery (FMBA) test or vasodilation response (VR) and by measuring plasma asymmetrical dimethylarginine (ADMA) in young adults born with LBW. Methods. In a retrospective cohort study, subjects were randomly selected from the Growth Study Cohort of Tanjungsari in the Sumedang district of West Java. They consisted of 67 LBW and 67 NBW (normal birth weight) young adults. Results. The relative risk for LBW to have low brachialis artery vasodilation response was 2.94, 95% confidence interval (CI): 1.91–4.53, and to have low plasma adiponectin concentration 1.53, (95 % CI: 1.07–2.18). Multivariate analysis via Hotelling’s trace showed a statistically significant difference (p < 0.001) for all variables studied (FMBA, plasma ADMA, and plasma adiponectin concentrations) but simultaneou