Add to ORKGA nonlinear elationship between the total area under the blood ethanol concentraton-tme curve and the orally administered ose (mg/kg) o / ethanol was observed in fasting subjects. A preliminary model, based on physiological considerations ~ was elaborated and shown, for the first time, to describe the entire time course of blood alcohol concentrations after four different doses of alcohol. The model could be refined by further experimentation. KEY WORDS: nonlinear pharmacokinetics; Michaelis-Menten kinetics; gastric emptying rate; blood alcohol concentrations
Given a set of differential equations describing blood alcohol content as a function time, we integr...
The concentration-time profiles of ethanol were deter-mined for capillary blood, end-expired breath,...
Given a set of differential equations describing blood alcohol content as a function time, we integr...
A nonlinear relationship between the total area under the blood ethanol concentration-time curve and...
The pharmacokinetics (PK) of ethanol are important in pharmacology and therapeutics because of poten...
The time course of ethanol disappearance from the blood has been examined in normal males and female...
The time course of ethanol disappearance from the blood has been examined in normal males and female...
The time course of ethanol disappearance from the blood has been examined in normal males and female...
Abstract — Seventy-four (44 under fasting conditions and 30 following oral liquid meals) sets of pos...
Eight male and 8 female subjects underwent serial breath alcohol concentration (BrAC) measurements i...
Eight male and 8 female subjects underwent serial breath alcohol concentration (BrAC) measurements i...
A physiologically based pharmacokinetic (PBPK) modeling approach was used to simulate the concentrat...
Abstract — The time course of ethanol disappearance from the blood has been examined in normal males...
The absorption rate of alcohol is one of the determinants of the peak blood alcohol concentration. S...
Background: Both the amount and the rate of absorption of ethanol (EtOH) from alcoholic bever-ages a...
Given a set of differential equations describing blood alcohol content as a function time, we integr...
The concentration-time profiles of ethanol were deter-mined for capillary blood, end-expired breath,...
Given a set of differential equations describing blood alcohol content as a function time, we integr...
A nonlinear relationship between the total area under the blood ethanol concentration-time curve and...
The pharmacokinetics (PK) of ethanol are important in pharmacology and therapeutics because of poten...
The time course of ethanol disappearance from the blood has been examined in normal males and female...
The time course of ethanol disappearance from the blood has been examined in normal males and female...
The time course of ethanol disappearance from the blood has been examined in normal males and female...
Abstract — Seventy-four (44 under fasting conditions and 30 following oral liquid meals) sets of pos...
Eight male and 8 female subjects underwent serial breath alcohol concentration (BrAC) measurements i...
Eight male and 8 female subjects underwent serial breath alcohol concentration (BrAC) measurements i...
A physiologically based pharmacokinetic (PBPK) modeling approach was used to simulate the concentrat...
Abstract — The time course of ethanol disappearance from the blood has been examined in normal males...
The absorption rate of alcohol is one of the determinants of the peak blood alcohol concentration. S...
Background: Both the amount and the rate of absorption of ethanol (EtOH) from alcoholic bever-ages a...
Given a set of differential equations describing blood alcohol content as a function time, we integr...
The concentration-time profiles of ethanol were deter-mined for capillary blood, end-expired breath,...
Given a set of differential equations describing blood alcohol content as a function time, we integr...