Different protocols of chemically induced hepatocarcinogenesis were applied to Wisfar rats under identical experimental conditions. The following conclu-sions may be drawn after an analytic comparison of these results. Various chemical carcinogens show different carcinogenic capacities. Diethylnitrosa-mine is more potent than N-nitrosomorpholine which i s more active than 2-acetylaminofluorene. A short-term exposure to such carcinogens is sufficient to initiate but not necessarily to complete the carcinogenic process. It can be promoted to completion by either a noncarcinogenic promoter or a carcinogen. From a systemic point of view, it appears that, as in the skin models, two-step protocols are not always equivalent to protocols using the ...
*To whom correspondence should be addressed Initiation activities of endogenously formed Ar-nitrosob...
Abstract: This study was conducted to determine the concordance of results for a pair of structural ...
Partial hepatectomy 24 h before a single i.p. dose of dimethylnitrosamine, diethylnitrosamine or eth...
Different protocols of chemically induced hepatocarcinogenesis were applied to Wistar rats under ide...
The aim of this work is to compare several experimental protocols inducing hepatocarcinogenesis in t...
Using a triphasic protocol recently described to induce malignant tumors in rat liver, the question ...
Hepatocellular carcinoma (HCC) is one of the most life-threatening cancers. The present study was de...
Hepatocellular carcinoma (HCC) is one of the most life-threatening cancers. The present study was de...
Background. One established model to induce hepatic preneoplasia (HP) (DEN 150) uses diethylnitrosam...
Our earlier studies have revealed that direct hyperplasia induced by liver mitogens such as lead nit...
In order to investigate whether different 'promoters' have the same qualitative and/or quantitative ...
SIGLECNRS T 64477 MIC / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
The capacities of nitrosamines to induce DNA single-strand breaks (SSB) and to initiate carcinogenes...
Experiments were designed to determine the role of cell proliferation in the initiation of liver car...
Experiments were designed to determine the role of cell proliferation in the initiation of liver car...
*To whom correspondence should be addressed Initiation activities of endogenously formed Ar-nitrosob...
Abstract: This study was conducted to determine the concordance of results for a pair of structural ...
Partial hepatectomy 24 h before a single i.p. dose of dimethylnitrosamine, diethylnitrosamine or eth...
Different protocols of chemically induced hepatocarcinogenesis were applied to Wistar rats under ide...
The aim of this work is to compare several experimental protocols inducing hepatocarcinogenesis in t...
Using a triphasic protocol recently described to induce malignant tumors in rat liver, the question ...
Hepatocellular carcinoma (HCC) is one of the most life-threatening cancers. The present study was de...
Hepatocellular carcinoma (HCC) is one of the most life-threatening cancers. The present study was de...
Background. One established model to induce hepatic preneoplasia (HP) (DEN 150) uses diethylnitrosam...
Our earlier studies have revealed that direct hyperplasia induced by liver mitogens such as lead nit...
In order to investigate whether different 'promoters' have the same qualitative and/or quantitative ...
SIGLECNRS T 64477 MIC / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
The capacities of nitrosamines to induce DNA single-strand breaks (SSB) and to initiate carcinogenes...
Experiments were designed to determine the role of cell proliferation in the initiation of liver car...
Experiments were designed to determine the role of cell proliferation in the initiation of liver car...
*To whom correspondence should be addressed Initiation activities of endogenously formed Ar-nitrosob...
Abstract: This study was conducted to determine the concordance of results for a pair of structural ...
Partial hepatectomy 24 h before a single i.p. dose of dimethylnitrosamine, diethylnitrosamine or eth...