Development of large-scale functional networks over the lifespan

The development of large-scale functional organization of the human brain across the lifespan is not well understood. Here we used magnetoencephalographic recordings of 53 adults (ages 18-89) to characteri ze functional brain networks in the resting state. Slow frequencies engage larger networks than higher frequencies and show different development over the lifespan. Networks in the delta (2- 4 Hz) frequency range decrease, while networks in the beta/gamma frequency range (> 16 Hz) increase in size with advancing age. Results show that the right frontal lobe and the temporal areas in both hemispheres are important relay stations in the expanding hi g h-frequency networks. Neuropsychological tes ts confirmed the tendency of cognitive decl ine wi th older age. The decrease in visual memory and visuoconstructive functions was strongly associated with the age-dependent enhancement of functional connectivity in both tem poral lobes. Using functional network analysis this study elucidates important neuronal principles underlying age-related cognitive decline p aving mental deterioration in senescence