National Institutes of Health (1). This trial showed

The past few years have been exciting for thoseof us who treat persons with diabetes. After decades of debate, the evidence that diabetes treat-ment can prevent or markedly reduce many of the long-term complications of the disease has now be-come overwhelming. Recent epidemiologic and pro-spective therapeutic trials examining this hypothesis have found that glycemic control will reduce the microvascular complications of diabetes in patients with either type of the disease (Table). The pivotal trial for patients with type 1 diabetes was the Dia-betes Control and Complications Trial, a 10-year trial that was reported in 1993 and sponsored by th