First Otoliths/Collagen/Bacterial Cellulose Nanocomposites as a Potential Scaffold for Bone Tissue Regeneration

In the present work, we report the first bionanocomposite material formed by otoliths / collagen / bacterial cellulose (BC) networks (OCBC). This biomaterial is an osteoinductor or be, stimulates the bone regeneration, enabling bigger migra-tion of the cells for formation of the bone tissue regeneration mainly because nanotolith are rich in minerals considered essential to the bone mineralization process on a protein matrix (otolin). The objective in this study was to analyze the regeneration capacity of bone defects treated with this bionanocomposite. Histological experiments shows bone tissue formation with high regularity, higher osteoblast activity and osteo-reabsorption activities areas. The results suggest the potential for this new biomaterial as a scaffold for bone tissue regeneration