Add to ORKGWe previously reported enhanced cerebrovascular remodeling and arteriogenesis in experimental type 2 diabetes. This study tested the hypotheses that 1) cerebral but not peripheral angio-genesis is increased in a spatial manner and 2) peroxynitrite orchestrates vascular endothelial growth factor (VEGF)-mediated brain angiogenesis in diabetes. Stereology of brain, eye, and skel-etal muscle microvasculature was evaluated in control and dia-betic rats using three-dimensional images. Migration and tube formation properties of brain microvascular endothelial cells (BMECs) were analyzed as markers of angiogenesis. Vascular density, volume, and surface area were progressively increased from rostral to caudal sections in both the cerebral cortex and...
The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus ...
Background and Purpose—Although the incidence of type II diabetes is increasing, very little is know...
International audienceThis study aimed at characterizing the impact of type 2 diabetes mellitus (T2D...
We previously reported enhanced cerebrovascular remodeling and arteriogenesis in experimental type 2...
<div><p>We previously reported intense pial cerebral collateralization and arteriogenesis in a mild ...
Dysregulation of cerebral vascular function and, ultimately, ce-rebral blood flow (CBF) may contribu...
We have previously shown that diabetes causes dysfunctional cerebral neovascularization that increas...
Background: Vascular complications of diabetes are due in part to impaired angiogenesis. The extent ...
<p>(A) Vascular density is significantly increased in both cortex and striatum of GK rats and this w...
Abstract Background Interruption of flow through of cerebral blood vessels results in acute ischemic...
AbstractAimsWe have shown that diabetes causes cerebrovascular remodeling in part by the activation ...
Ephrin-B2 was decreased in cerebral pericytes using AAV viral injection. Animals were perfused with ...
An enriched environment (EE) has been demonstrated to improve functional recovery in animal models o...
Pericytes provide vascular stability and control endothelial proliferation. Pericyte loss, microaneu...
Increasing evidence points to inflammation as a key factor in the pathogenesis of diabetic retinopat...
The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus ...
Background and Purpose—Although the incidence of type II diabetes is increasing, very little is know...
International audienceThis study aimed at characterizing the impact of type 2 diabetes mellitus (T2D...
We previously reported enhanced cerebrovascular remodeling and arteriogenesis in experimental type 2...
<div><p>We previously reported intense pial cerebral collateralization and arteriogenesis in a mild ...
Dysregulation of cerebral vascular function and, ultimately, ce-rebral blood flow (CBF) may contribu...
We have previously shown that diabetes causes dysfunctional cerebral neovascularization that increas...
Background: Vascular complications of diabetes are due in part to impaired angiogenesis. The extent ...
<p>(A) Vascular density is significantly increased in both cortex and striatum of GK rats and this w...
Abstract Background Interruption of flow through of cerebral blood vessels results in acute ischemic...
AbstractAimsWe have shown that diabetes causes cerebrovascular remodeling in part by the activation ...
Ephrin-B2 was decreased in cerebral pericytes using AAV viral injection. Animals were perfused with ...
An enriched environment (EE) has been demonstrated to improve functional recovery in animal models o...
Pericytes provide vascular stability and control endothelial proliferation. Pericyte loss, microaneu...
Increasing evidence points to inflammation as a key factor in the pathogenesis of diabetic retinopat...
The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus ...
Background and Purpose—Although the incidence of type II diabetes is increasing, very little is know...
International audienceThis study aimed at characterizing the impact of type 2 diabetes mellitus (T2D...