1 Disease Progression in Mothers of Children Enrolled in the Research Registry for Neonatal Lupus

2 Objective. To evaluate autoimmune disease progression in asymptomatic and pauci-symptomatic mothers of children with neonatal lupus (NL). Methods. Clinical information on mothers enrolled in the Research Registry (RRNL) was obtained from medical records. Genotyping was performed for-308A/G TNFα, 869T/C TGFβ, and-889C/T IL1α. Results. Of the 321-mothers enrolled, 229 had at least six months of follow-up. Twenty-six of the fifty-one mothers who were asymptomatic at the NL-child’s birth progressed: 12 developed pauci-undifferentiated autoimmune syndrome (UAS), two poly-UAS, seven SS, four SLE and one SLE/SS. The median time to develop any symptom was 3.15 years. Sixteen of the 37 mothers classified as pauci-UAS at the NL-child’s birth progressed: five developed poly-UAS, six SS, four SLE, and one SLE/SS. Of the pauci-UAS mothers enrolled within one year, the median time to progression was 6.7 years. Four mothers developed lupus nephritis (two asymptomatic, two pauci-UAS). The probability of an asymptomatic mother developing SLE b