Early High-Dose Daptomycin for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections With Elevated Vancomycin Minimum Inhibitory

from a matched cohort study addressing the clinical conundrum of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections caused by organ-isms with elevated vancomycin minimum inhibitory concentrations (MICs) [1]. The investigators conclude that high-dose daptomycin treatment led to better outcomes, and they advocate for an early switch from vancomycin to daptomycin based on finding a vancomycin MIC>1 μg/mL. Although the study provides new insight into this important clinical problem, several key questions remain. A growing body of data shows that S. aureus isolates with higher vancomyci