Coronary collateral stimulation by exercise in dogs with stenotic coronary arteries

SCHEUER. Coronary collateral stimulatim by exercise in dogs with stenotic coronary arteries. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52 ( 3): 664-671,1982.-To determine the effects of an exercise-training program on coronary collat-eral development, we instrumented 13 l-y-r-old beagles with left circumflex (LCf) coronary artery flow probes and balloon oc-eluders and left atria1 and aortic catheters. The LCf artery was constricted resulting in a 58 * 4 % reduction of the peak reactive hyperemia response following release of a 15-s LCf occlusion. All dogs were studied during the first week of the study protocol. Resting heart rate, cardiac output, and left atria1 and aortic pressures were evaluated before and during a I-min LCf occlu-sion. Myocardial blood flow was also measured with radioac-tively-labeled microspheres injected into the left atrium during the LCf occlusion. Subsequently the dogs were exercised at 6.