Relation of plasma homocysteine to plasma amyloid beta levels

Abstract Background Elevated plasma homocyste-ine and amyloid b (Ab) have been associated with Alzheimer’s disease (AD). We investigated the cross-sectional association between these biomarkers. Methods We used linear regression to relate plasma homocysteine and Ab adjusting for age, gender, creatinine, APOE-e4, and ethnic group in 327 persons aged 78 ± 6.6 years. Results Plasma homocysteine correlated with age, serum creatinine, plasma Ab40 and Ab42, and was inversely correlated with serum vitamin B12, and folate. Ab42, but not Ab40, was related to later development of dementia. Homocysteine was related to higher Ab40 levels (coefficient = 2.0; P < 0.0001) and this association was attenuated after adjustmen