Background: Immune activation is a strong predictor of disease progression in HIV infection. Combinatorial plasma biomarker signatures that represent surrogate markers of immune activation in both viremic and aviremic HIV patients on combination antiretroviral therapy (cART) have not been defined. Here, we identify a plasma inflammatory biomarker signature that distinguishes between both viremic and aviremic HIV patients on cART and healthy controls and examine relationships of this signature to markers of disease progression. Methods: Multiplex profiling and ELISA were used to detect 15 cytokines/chemokines, soluble IL-2R (sIL-2R), and soluble CD14 (sCD14) in plasma from 57 HIV patients with CD4 nadir,300 cells/ml and 29 healthy controls. ...
This multicountry prospective study investigated whether persistent systemic inflammation, measured ...
<p>(A) Plasma sCD14 shows positive correlation with IL-6, IL-15, and trend towards significant corre...
Background: Both T-cell activation during early HIV-1 infection and soluble markers of immune activa...
Background: Immune activation is a strong predictor of disease progression in HIV infection. Combina...
<div><h3>Background</h3><p>Immune activation is a strong predictor of disease progression in HIV inf...
Background. Soluble biomarkers of inflammation predict non-AIDS related morbidity and mortality amon...
<p>Viral load, CD4+ T cell counts, sCD163, and sCD14 levels were used as progression biomarkers to c...
Few studies have examined immune activation profiles in patients with advanced HIV-1 subtype C infec...
Chronic immune activation is a hallmark of HIV infection and has been associated with disease progre...
BACKGROUND: HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretrovi...
T cell activation levels, viral load and CD4(+) T cell counts at early stages of HIV-1 infection are...
We evaluated immune biomarker profiles in HIV-infected adults (n=398) from 5 African countries. Alth...
Background: CXCL13 is preferentially secreted by Follicular Helper T cells (T-FH) to attract B cells...
HIV infection is characterized by a state of chronic activation of the immune system, which is not c...
<div><p>T cell activation levels, viral load and CD4<sup>+</sup> T cell counts at early stages of HI...
This multicountry prospective study investigated whether persistent systemic inflammation, measured ...
<p>(A) Plasma sCD14 shows positive correlation with IL-6, IL-15, and trend towards significant corre...
Background: Both T-cell activation during early HIV-1 infection and soluble markers of immune activa...
Background: Immune activation is a strong predictor of disease progression in HIV infection. Combina...
<div><h3>Background</h3><p>Immune activation is a strong predictor of disease progression in HIV inf...
Background. Soluble biomarkers of inflammation predict non-AIDS related morbidity and mortality amon...
<p>Viral load, CD4+ T cell counts, sCD163, and sCD14 levels were used as progression biomarkers to c...
Few studies have examined immune activation profiles in patients with advanced HIV-1 subtype C infec...
Chronic immune activation is a hallmark of HIV infection and has been associated with disease progre...
BACKGROUND: HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretrovi...
T cell activation levels, viral load and CD4(+) T cell counts at early stages of HIV-1 infection are...
We evaluated immune biomarker profiles in HIV-infected adults (n=398) from 5 African countries. Alth...
Background: CXCL13 is preferentially secreted by Follicular Helper T cells (T-FH) to attract B cells...
HIV infection is characterized by a state of chronic activation of the immune system, which is not c...
<div><p>T cell activation levels, viral load and CD4<sup>+</sup> T cell counts at early stages of HI...
This multicountry prospective study investigated whether persistent systemic inflammation, measured ...
<p>(A) Plasma sCD14 shows positive correlation with IL-6, IL-15, and trend towards significant corre...
Background: Both T-cell activation during early HIV-1 infection and soluble markers of immune activa...