Viewpoints Detection of Four Dengue Serotypes Suggests Rise in Hyperendemicity in Urban Centers of Brazil

Dengue fever is the most common infectious disease transmitted by a mosqui-to and a major economic and disease burden in endemic countries. The reported number of dengue cases in 2013 evidences the disease’s disturbing impact on human health in Brazil: 950,193 clinical cases, 3,749 with severe manifestations, and 201 deaths (data up to July 13, 2013 by the Pan American Health Organization); any of the four serotypes was the etiologic agent in different geographical regions. The epide-miological surveillance center ‘‘Prof. Alex-andre vranjac’ ’ documented in the state of São Paulo a total of 105,973 cases (data u