Bradykinin in reflex cardiovascular responses to static muscular contraction

kinin in reflex cardiovascular responses to static muscular con-traction. J. Appl. Physiol. 61(l): 271-279, 1986.-We examined the contribution of bradykinin to the reflex hemodynamic response evoked by static contraction of the hindlimb of anes-thetized cats. During electrical stimulation of ventral roots L, and S1, we compared the cardiovascular responses to hindlimb contraction before and after the following interventions: inhi-bition of converting enzyme (kininase II) with captopril (3-4 w/k, n = 6); inhibition of kallikrein activity with aprotinin (Trasylol, 20,000-30,000 KIU/kg, n = 8); and injection of carboxypeptidase B (500-750 U/kg, n = 7). Treatment with captopril augmented the rise in mean arterial blood pressure and maximal time derivative of pressure (dP/dt) caused by static contraction from 21 t 3 to 39 t 7 mmHg and 1,405-t-362 to 2,285 t 564 mmHg/s, respectively. Aprotinin attenuate