Add to ORKGWe are interested in developing gene therapy treatments for pulmonary diseases, including acute lung injury. We have demonstrated that electroporation efficiently delivers genes to the lung in vivo with no apparent damage and yields high level gene expression. The method is simple, fast, and safe: DNA is delivered to the airways and electrodes placed externally on the chest are used to deliver the field. In mouse and rat studies we have demonstrated that transfer of genes for the Na+,K+-ATPase and/or the Epithelial Sodium Channel protects from subsequent endotoxin-induced lung injury. We have also shown that this approach can be used in lungs with established lung injury to treat the disease and lessen the severity of the injury. To move th...
Gene transfer to the lung can be achieved via either the airway or the pulmonary vasculature. We eva...
Gene therapy may represent a promising alternative strategy for cardiac muscle regeneration. In vivo...
Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation atte...
BACKGROUND: Gene therapy applications require safe and efficient methods for gene transfer. Present ...
These results indicate that electroporation can be used to enhance gene transfer in the lungs of mic...
BACKGROUND: Existing methods of non-viral airway gene transfer suffer from low levels of efficiency....
Aim of the Study: Nucleic acid-based therapies have the potential to provide clinically meaningful b...
Electroporation refers to a technique that makes use of electrical pulses to create transient and re...
In vivo gene transfer to the ischemic heart via electroporation holds promise as a potential therape...
This thesis addresses the critically poor efficacy of existing strategies to treat lung disease. A n...
Our lab has previously demonstrated that cytoplasmic trafficking and subsequent nuclear entry of non...
Background: Gene therapy is a promising approach for the treatment of various diseases, including ca...
Gene therapy may represent a promising alternative strategy for cardiac muscle regeneration. In vivo...
Gene therapy may represent a promising alternative strategy for cardiac muscle regeneration. In vivo...
In vivo gene transfer to the ischemic heart via electroporation holds promise as a potential therape...
Gene transfer to the lung can be achieved via either the airway or the pulmonary vasculature. We eva...
Gene therapy may represent a promising alternative strategy for cardiac muscle regeneration. In vivo...
Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation atte...
BACKGROUND: Gene therapy applications require safe and efficient methods for gene transfer. Present ...
These results indicate that electroporation can be used to enhance gene transfer in the lungs of mic...
BACKGROUND: Existing methods of non-viral airway gene transfer suffer from low levels of efficiency....
Aim of the Study: Nucleic acid-based therapies have the potential to provide clinically meaningful b...
Electroporation refers to a technique that makes use of electrical pulses to create transient and re...
In vivo gene transfer to the ischemic heart via electroporation holds promise as a potential therape...
This thesis addresses the critically poor efficacy of existing strategies to treat lung disease. A n...
Our lab has previously demonstrated that cytoplasmic trafficking and subsequent nuclear entry of non...
Background: Gene therapy is a promising approach for the treatment of various diseases, including ca...
Gene therapy may represent a promising alternative strategy for cardiac muscle regeneration. In vivo...
Gene therapy may represent a promising alternative strategy for cardiac muscle regeneration. In vivo...
In vivo gene transfer to the ischemic heart via electroporation holds promise as a potential therape...
Gene transfer to the lung can be achieved via either the airway or the pulmonary vasculature. We eva...
Gene therapy may represent a promising alternative strategy for cardiac muscle regeneration. In vivo...
Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation atte...