Abstract—Lipoprotein lipase (LPL) hydrolyzes triglycerides in the circulation and promotes the hepatic uptake of remnant lipoproteins. Since the gene was cloned in 1989, more than 100 LPL gene mutations have been identified, the majority of which cause loss of enzymatic function. In contrast to this, the naturally occurring LPLS447X variant is associated with increased lipolytic function and an anti-atherogenic lipid profile and can therefore be regarded as a gain-of-function mutation. This notion combined with the facts that 20 % of the general population carries this prematurely truncated LPL and that it may protect against cardiovascular disease has led to extensive clinical and basic research into this frequent LPL mutant. It is only un...
Background: Atherosclerotic cardiovascular disease is the main cause of mortality worldwide and is s...
Hyperlipidemia is a major risk factor for coronary artery disease (CAD). Lipoprotein lipase (LPL) is...
Background Type 1 hyperlipoproteinemia is a rare autosomal recessive disorder most often caused by m...
Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipopro...
Objective—Lipoprotein lipase (LPL) exerts 2 principal actions, comprising enzymatic hydrolysis of tr...
Lipoprotein lipase (LPL) is a critical enzyme which primary function is to hydrolyze triglycerides ...
IMPORTANCE The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyc...
Importance: The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing trigly...
Endothelial lipase is a phospholipase with activity against high-density lipoprotein. Although a sma...
BACKGROUND: Lipoprotein lipase (LPL) is the rate-limiting enzyme in the lipolysis of triglyceride-ri...
A reduction of high density lipoprotein cholesterol (HDC) is recognized as an important risk factor ...
This report describes the association between a frequent mutation in the lipoprotein lipase (LPL) ge...
Triglyceride (TG) metabolism is crucial for whole body and local energy homeostasis and accumulating...
We screened 160 unrelated Chinese hypertriglyceridemic subjects for sequence alterations in the prom...
Lipoprotein lipase (LPL) is a key enzyme involved with hydrolysis and removal of triglycerides from ...
Background: Atherosclerotic cardiovascular disease is the main cause of mortality worldwide and is s...
Hyperlipidemia is a major risk factor for coronary artery disease (CAD). Lipoprotein lipase (LPL) is...
Background Type 1 hyperlipoproteinemia is a rare autosomal recessive disorder most often caused by m...
Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipopro...
Objective—Lipoprotein lipase (LPL) exerts 2 principal actions, comprising enzymatic hydrolysis of tr...
Lipoprotein lipase (LPL) is a critical enzyme which primary function is to hydrolyze triglycerides ...
IMPORTANCE The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyc...
Importance: The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing trigly...
Endothelial lipase is a phospholipase with activity against high-density lipoprotein. Although a sma...
BACKGROUND: Lipoprotein lipase (LPL) is the rate-limiting enzyme in the lipolysis of triglyceride-ri...
A reduction of high density lipoprotein cholesterol (HDC) is recognized as an important risk factor ...
This report describes the association between a frequent mutation in the lipoprotein lipase (LPL) ge...
Triglyceride (TG) metabolism is crucial for whole body and local energy homeostasis and accumulating...
We screened 160 unrelated Chinese hypertriglyceridemic subjects for sequence alterations in the prom...
Lipoprotein lipase (LPL) is a key enzyme involved with hydrolysis and removal of triglycerides from ...
Background: Atherosclerotic cardiovascular disease is the main cause of mortality worldwide and is s...
Hyperlipidemia is a major risk factor for coronary artery disease (CAD). Lipoprotein lipase (LPL) is...
Background Type 1 hyperlipoproteinemia is a rare autosomal recessive disorder most often caused by m...