Add to ORKGA library of novel, highly functionalized spiropyrrolidines has been synthesized stereoselectively for the first time in ionic liquid medium employing [3þ2] cycloaddition of a series of 2-arylmethylidene-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ones with an unexplored azomethine ylide derived from acenaphthenequinone or isatin and tryptophan. These compounds were evaluated in vitro for their acetylcholinesterase and butyrylcholinesterase inhibitory activities. Molecular modelling simulationwas performed to determine the binding interaction and orientation of thesemolecules in the active site gorge of the respective receptors
WOS: 000385175500024A series of N-{2-[2-(1H-benzimidazole-2-yl)phenoxy]ethyl} substituted amine deri...
Novel N-substituted phthalimide derivatives (4a-c) were synthesized using a three-step procedure in ...
Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containi...
A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bm...
A series of hitherto unreported piperidone embedded α,β- unsaturated ketones were synthesized effici...
A novel spiroheterocyclic hybrid comprising several privileged structures comprising pyrrolidine, qu...
International audienceA novel one-pot [3+2]-cycloaddition reaction of (E)-3-arylidene-1-phenyl-succi...
Five new series of new spiro-oxindole-pyrrolizine and pyrrolidine hybrids were synthesized employin...
Twenty-five new hits of spirooxindole analogs 8a–y engrafted with indole and pyrazole scaffolds were...
International audienceA series of new dispiro pyrrolidines were regioselectively synthesised via [3+...
In the effort of finding novel acetyl cholinesterase (AChE) inhibitors to improve the efficacy of Al...
Monocationic and dicationic cholinium ionic liquids (ILs) were synthesized and evaluated as acetylch...
Abstract In this study, a new series of spiro indolin-1,2-diazepine were designed, synthesized, and ...
Abstract: Cholinesterases (ChEs) play a vital role in the regulation of cholinergic transmission. Th...
New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-pot fa...
WOS: 000385175500024A series of N-{2-[2-(1H-benzimidazole-2-yl)phenoxy]ethyl} substituted amine deri...
Novel N-substituted phthalimide derivatives (4a-c) were synthesized using a three-step procedure in ...
Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containi...
A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bm...
A series of hitherto unreported piperidone embedded α,β- unsaturated ketones were synthesized effici...
A novel spiroheterocyclic hybrid comprising several privileged structures comprising pyrrolidine, qu...
International audienceA novel one-pot [3+2]-cycloaddition reaction of (E)-3-arylidene-1-phenyl-succi...
Five new series of new spiro-oxindole-pyrrolizine and pyrrolidine hybrids were synthesized employin...
Twenty-five new hits of spirooxindole analogs 8a–y engrafted with indole and pyrazole scaffolds were...
International audienceA series of new dispiro pyrrolidines were regioselectively synthesised via [3+...
In the effort of finding novel acetyl cholinesterase (AChE) inhibitors to improve the efficacy of Al...
Monocationic and dicationic cholinium ionic liquids (ILs) were synthesized and evaluated as acetylch...
Abstract In this study, a new series of spiro indolin-1,2-diazepine were designed, synthesized, and ...
Abstract: Cholinesterases (ChEs) play a vital role in the regulation of cholinergic transmission. Th...
New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-pot fa...
WOS: 000385175500024A series of N-{2-[2-(1H-benzimidazole-2-yl)phenoxy]ethyl} substituted amine deri...
Novel N-substituted phthalimide derivatives (4a-c) were synthesized using a three-step procedure in ...
Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containi...