Add to ORKGInterleukin-7 (IL-7) is a glycoprotein that regulates lympho-cyte precursor growth and differentiation. However, the exact mechanism whereby the IL-7 receptor (IL-7R) mediates these cell growth signals remains unknown. One of the earliest meta-bolic events linked to mitogenic responses in other growth fac-tor receptor systems is the activation of phosphatidylinositol-3 kinase (PI-3 kinase). We demonstrate here that ligation of the IL-7R results in dose- and time-dependent increases in PI-3 kinase activity. These results suggest that PI-3 kinase is in-volved in signal transduction via the IL-7R in human thymo-cytes. (J. Clin. Invest. 1993.92:1559-1563.) Key words: phos-phatidylinositol * phosphatidylinositol 3 phosphate * phospha-tidylinosit...
The development of T lymphocytes in the thymus and the function of mature T cells in adaptive immune...
Cytokines have been shown to have important roles in lymphopoiesis. However, many questions remain u...
The cytokine Interleukin-7 (IL-7) is critical for T cell development and function. Mutations that bl...
AbstractHere, we define the IL-7R-activated signal that promotes survival and proliferation of T cel...
IL-7 is essential for the development and survival of T lymphocytes. This review is primarily from t...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2009.In title on title pag...
© 2004 The Rockefeller University PressInterleukin (IL)-7 is essential for normal T cell development...
The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and result...
CD7 is a 40-kDa glycoprotein that is expressed on prothymocytes and persists during T cell different...
The cytokine interleukin (IL)-7 is necessary for human T cell development and murine B and T lymphop...
The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and result...
Phosphatidylinositol 3-kinase (PI 3-kinase) is activated by the cytokine interleukin-2 (IL-2). We ha...
Background: A delicate balance between positive and negative regulatory mechanisms during T-cell act...
Signals transduced through the T cell receptor (TCR) lead to T cell differentiation, proliferation, ...
Human CD7 is a 40 kDa protein expressed on thymocytes, early T, B, NK and myeloid lineage cells in b...
The development of T lymphocytes in the thymus and the function of mature T cells in adaptive immune...
Cytokines have been shown to have important roles in lymphopoiesis. However, many questions remain u...
The cytokine Interleukin-7 (IL-7) is critical for T cell development and function. Mutations that bl...
AbstractHere, we define the IL-7R-activated signal that promotes survival and proliferation of T cel...
IL-7 is essential for the development and survival of T lymphocytes. This review is primarily from t...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2009.In title on title pag...
© 2004 The Rockefeller University PressInterleukin (IL)-7 is essential for normal T cell development...
The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and result...
CD7 is a 40-kDa glycoprotein that is expressed on prothymocytes and persists during T cell different...
The cytokine interleukin (IL)-7 is necessary for human T cell development and murine B and T lymphop...
The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and result...
Phosphatidylinositol 3-kinase (PI 3-kinase) is activated by the cytokine interleukin-2 (IL-2). We ha...
Background: A delicate balance between positive and negative regulatory mechanisms during T-cell act...
Signals transduced through the T cell receptor (TCR) lead to T cell differentiation, proliferation, ...
Human CD7 is a 40 kDa protein expressed on thymocytes, early T, B, NK and myeloid lineage cells in b...
The development of T lymphocytes in the thymus and the function of mature T cells in adaptive immune...
Cytokines have been shown to have important roles in lymphopoiesis. However, many questions remain u...
The cytokine Interleukin-7 (IL-7) is critical for T cell development and function. Mutations that bl...