3Departament of Pharmacology and Pharmacy

Abstract: Until the 80 ’ of the last century aluminium was considered as a non or less toxic element. Further researches pointed out more and more the negative impact of aluminium on environment, human and animal health. Aluminium reproductive toxicity is a newer domain of concern. The information about the aluminium impact on female reproductive system integrity and performances markers is few and sometimes controversially [2, 3, 5, 7, 8, 9].The aim of the study was to evaluate aluminium reproductive toxicity. The concrete objectives were: evaluation of the sexuale cycle characteristics, duration and regularity in female rats. MATERIAL AND METHODS The study was carried out during six month on 32 white Wistar adult female rats divided in four groups: three experimental (E) and one control (C). The E groups received aluminium sulphate in drinking water as follows: E1: 200 ppb Al (exceptional admitted level in drinking water according to Romanian Law No 485/2002); E2: 400 ppb Al; E3: 1000 ppb Al, the last two being concentrations found in drinking water from wells for animals and humans in areas with aluminium contamination risk. The C group received tape water containing max: 50 ppb Al (maximum admitted level by Romanian Law 485/2002). The evaluation of the fundamental markers of the reproductive function was based on the daily examination of vaginal smear staine