Add to ORKG4-Vinylcyclohexene (VCH), an occupational chemical, causes destruction of small preantral follicles (F1) in mice. Previous studies suggested that VCH is bioactivated via cytochromes P450 (CYP450) to the ovotoxic, diepoxide metabolite, VCD. Whereas hepatic CYP450 isoforms 2E1, 2A, and 2B can metabolize VCH, the role of ovarian metabolism is unknown. This study investi-gated expression of these isoforms in isolated ovarian fractions (F1, 25–100 m; F2, 100–250 m; F3,>250 m; interstitial cells, Int) from B6C3F1 mice dosed daily (15 days; ip) with vehicle, VC
Exposure of females to environmental chemicals can disrupt reproductive function by altering the nor...
The follicle-depleted postmenopausal ovary is enriched in in-terstitial cells that produce androgens...
4-vinylcyclohexene diepoxide (VCD) is a metabolite of 4-vinylcyclohexene (VCH) which has the potenti...
4-Vinylcyclohexene (VCH), an industrial chemical, causes destruction of small pre-antral follicles (...
4-Vinylcyclohexene (VCH) is an ovarian toxicant in mice that requires bioactivation to epoxides to c...
Ovarian toxicants 4-vinylcychlohexene (VCH) and 7,12-dimethylbenz[a]anthracene (DMBA) requires bioac...
Microsomal epoxide hydrolase (mEH) is involved in the detox-ification of xenobiotics that are or can...
D ow nloaded from 2Abstract: 4-Vinylcyclohexene (VCH), an occupational chemical, causes destruction ...
4-vinylcyclohexene diepoxide (VCD) is a metabolite of 4-vinylcyclohexene (VCH) which has the potenti...
4-Vinylcyclohexene (VCH) is an intermediate in the production of rubber and styrene. Following repea...
Female mammals are born with a nite number of ovarian primordial follicles that cannot be regenerat...
The occupational chemicals 4-vinylcyclohexene (VCH) and butadiene diepoxide (BDE) have shown an ovar...
The basis for the species difference between B6C3F1 mice (susceptible) and Fischer 344 rats (resista...
Polycyclic aromatic hydrocarbons (PAHs) are environmental ovotoxicants commonly released in cigarett...
4-Vinyl-1-cyclohexene diepoxide (VCD) is a known carcinogen, a direct acting mutagen, and an ovarian...
Exposure of females to environmental chemicals can disrupt reproductive function by altering the nor...
The follicle-depleted postmenopausal ovary is enriched in in-terstitial cells that produce androgens...
4-vinylcyclohexene diepoxide (VCD) is a metabolite of 4-vinylcyclohexene (VCH) which has the potenti...
4-Vinylcyclohexene (VCH), an industrial chemical, causes destruction of small pre-antral follicles (...
4-Vinylcyclohexene (VCH) is an ovarian toxicant in mice that requires bioactivation to epoxides to c...
Ovarian toxicants 4-vinylcychlohexene (VCH) and 7,12-dimethylbenz[a]anthracene (DMBA) requires bioac...
Microsomal epoxide hydrolase (mEH) is involved in the detox-ification of xenobiotics that are or can...
D ow nloaded from 2Abstract: 4-Vinylcyclohexene (VCH), an occupational chemical, causes destruction ...
4-vinylcyclohexene diepoxide (VCD) is a metabolite of 4-vinylcyclohexene (VCH) which has the potenti...
4-Vinylcyclohexene (VCH) is an intermediate in the production of rubber and styrene. Following repea...
Female mammals are born with a nite number of ovarian primordial follicles that cannot be regenerat...
The occupational chemicals 4-vinylcyclohexene (VCH) and butadiene diepoxide (BDE) have shown an ovar...
The basis for the species difference between B6C3F1 mice (susceptible) and Fischer 344 rats (resista...
Polycyclic aromatic hydrocarbons (PAHs) are environmental ovotoxicants commonly released in cigarett...
4-Vinyl-1-cyclohexene diepoxide (VCD) is a known carcinogen, a direct acting mutagen, and an ovarian...
Exposure of females to environmental chemicals can disrupt reproductive function by altering the nor...
The follicle-depleted postmenopausal ovary is enriched in in-terstitial cells that produce androgens...
4-vinylcyclohexene diepoxide (VCD) is a metabolite of 4-vinylcyclohexene (VCH) which has the potenti...