Genetic mapping of quantitative trait loci influencing left ventricular mass in rats

Kinoshita. Genetic mapping of quantitative trait loci influ-encing left ventricular mass in rats. Am J Physiol Heart Circ Physiol 279: H2062–H2067, 2000.—High blood pressure is the leading cause of left ventricular hypertrophy (LVH); however, not all hypertensive patients develop LVH. Genetic factors are important in the development of LVH. With the use of F2 male rats from spontaneously hypertensive rats and Lewis rats, we performed a study to identify the quan-titative trait loci (QTL) that influence left ventricular mass (LVM). Mean arterial pressure (MAP) was measured by the direct intra-arterial method in conscious animals, and LVM was determined at 24 wk of age. QTL analysis was done using 160 microsatellite markers for a genome-wide scan. Two loci that influenced body weight-adjusted LVM with logarithm of the odds scores.3.4 were found. One locus o