10.1177/1757177413520186 VOL. XX NO. X Month 201X Journal of Infection Prevention 1

re vi ew ed a rti cl e entral line associated bloodstream infection (CLABSI) reduction programmes in hospitalised children have been focused in the intensive care setting and little data is available on the efficacy and cost effectiveness of such programmes in other clini-cal areas. Prospective monitoring of hospital acquired CLABSI rates in all clinical areas was performed at [name of institution removed] for a period of three years follow-ing the implementation of a central venous line (CVL) care bundle. We observed a decrease in CLABSI rates from 220 in the first year following intervention to 108 per 100,000 patient days (p=0.002) in the third year of the study, demonstrating a decrease of over 50 % in CLABSI rates. Blood culture contamination rates were also sig-nificantly reduced. The introduction of a CVL care bundle produced a significant, sustainable reduction in hospital acquired CLABSI rates in a children’s hospital setting. Background and aims Central line associated bloodstream infection (CLABSI) in hospital-ised children leads to significant morbidity and mortality, but also represents a significant financial burden. The cost of a CLABSI in the NHS has previously been evaluated at £6,209 (National Audit Office, 2000). A central venous line (CVL) maintenance care bundle, follow