Electrostimulation on the Rest-Activity Rhythm and Salivary Cortisol in Alzheimer’s Disease A Pilot Study

high-frequency CES. In contrast, both groups showed an in-crease in the level of cortisol after the 6-week treatment pe-riod. Conclusions: High-frequency CES appeared to be inef-fective in AD patients. Copyright © 2006 S. Karger AG, Basel In previous studies, transcutaneous electrical nerve stimulation, a type of peripheral nerve stimulation, ap-peared to strengthen the coupling of the rest-activity rhythm to supposedly stable zeitgebers in patients with Alzheimer’s disease (AD) [1, 2]. Moreover, AD patients showed a decrease in nocturnal restlessness. Another type of mild electrical stimulation that is partly mediated by the peripheral nervous system is cranial electrostimu-lation (CES). It was observed that CES improved sleep quality after 2 weeks of treatment in older people wit