Quantitative and Morphological Changes in Neurons and Neuroglia in the Indusium Griseum of Aging Mice

The indusium griseum was investigated quantitatively in 5-mo-old and 18-mo-old mice. There was no difference in the number of neurons between 5 and 18 mo, but the number of neuroglia increased by almost 309f. Astrocytes and microglia increased in number, but oligodendrocyte number remained unchanged. There was no significant variation in the volume density of neuronal perikaryon, neuropil, or blood vessels with age. A LTHOUGH most quantitative studies ofaging cerebral cortex have shown an increase in neuroglial numbers with increasin