Structural bioinformatics PROVAT: a tool for Voronoi tessellation analysis of protein structures and complexes

Summary: Voronoi tessellation has proved to be a useful tool in protein structure analysis. We have developed PROVAT, a versatile public domain software that enables computation and visualization of Voronoi tessellations of proteins and protein complexes. It is a set of Python scripts that integrate freely available specialized soft-ware (Qhull, Pymol etc.) into a pipeline. The calculation component of the tool computes Voronoi tessellation of a given protein system in a way described by a user-supplied XML recipe and stores resulting neighbourhood information as text files with various styles. The Python pickle file generated in the process is used by the visualization com-ponent, a Pymol plug-in, that offers a GUI to explore the tessellation visually. Availability: PROVAT source code can be downloaded fro