OBJECTIVE—The fuel sensor AMP-activated protein kinase (AMPK) in the hypothalamus regulates energy homeostasis by sensing nutritional and hormonal signals. However, the role of hypothalamic AMPK in glucose production regulation remains to be elucidated. We hypothesize that bidirectional changes in hypothalamic AMPK activity alter glucose production. RESEARCH DESIGN AND METHODS—To introduce bidirec-tional changes in hypothalamic AMPK activity in vivo, we first knocked down hypothalamic AMPK activity in male Sprague-Dawley rats by either injecting an adenovirus expressing the dominant-negative form of AMPK (Ad-DN AMPK2 [D157A]) or infusing AMPK inhibitor compound C directly into the medio-basal hypothalamus. Next, we independently activated h...
OBJECTIVE—Hypothalamic nutrient sensing regulates glucose production, but the neuronal circuits invo...
The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy sta...
AMP-activated protein kinase (AMPK) is a cellular energy sensor that exists in almost all eukaryotes...
OBJECTIVE—The fuel sensor AMP-activated protein kinase (AMPK) in the hypothalamus regulates energy h...
Hypothalamic AMP-activated protein kinase (AMPK) regulates energy homeostasis in response to nutriti...
The mechanisms by which specialized glucose-sensing neurons within the hypothalamus are able to dete...
OBJECTIVE-To examine in vivo in a rodent model the potential role of AMP-activated protein kinase (A...
OBJECTIVE—To examine in vivo in a rodent model the poten-tial role of AMP-activated protein kinase (...
Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular ene...
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanis...
Insulin signaling in the brain is vital to maintain whole-body glucose and energy homeostasis. AMP-a...
Defective counterregulatory responses (CRRs) to hypoglycemia are associated with a marked increase i...
Aims/hypothesis: Hypothalamic glucose-excited (GE) neurons contribute to whole-body glucose homeosta...
The AMPK (AMP-activated protein kinase) is a highly conserved eukaryotic protein serine/threonine ki...
OBJECTIVE—Hypothalamic nutrient sensing regulates glucose production, but the neuronal circuits invo...
The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy sta...
AMP-activated protein kinase (AMPK) is a cellular energy sensor that exists in almost all eukaryotes...
OBJECTIVE—The fuel sensor AMP-activated protein kinase (AMPK) in the hypothalamus regulates energy h...
Hypothalamic AMP-activated protein kinase (AMPK) regulates energy homeostasis in response to nutriti...
The mechanisms by which specialized glucose-sensing neurons within the hypothalamus are able to dete...
OBJECTIVE-To examine in vivo in a rodent model the potential role of AMP-activated protein kinase (A...
OBJECTIVE—To examine in vivo in a rodent model the poten-tial role of AMP-activated protein kinase (...
Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular ene...
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanis...
Insulin signaling in the brain is vital to maintain whole-body glucose and energy homeostasis. AMP-a...
Defective counterregulatory responses (CRRs) to hypoglycemia are associated with a marked increase i...
Aims/hypothesis: Hypothalamic glucose-excited (GE) neurons contribute to whole-body glucose homeosta...
The AMPK (AMP-activated protein kinase) is a highly conserved eukaryotic protein serine/threonine ki...
OBJECTIVE—Hypothalamic nutrient sensing regulates glucose production, but the neuronal circuits invo...
The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy sta...
AMP-activated protein kinase (AMPK) is a cellular energy sensor that exists in almost all eukaryotes...