Pharmacodynamic Study of F(ab')2 Fragments of Murine Monoclonal Antibody 7E3 Directed against Human Platelet Glycoprotein lDb/lila in Patients with Unstable Angina Pectoris

The pharmacodynamics of intravenous bolus injections of 0.05, 0.10, 0.15, and 0.20 mg/kg of F(ab')2 fragments of the murine monoclonal antibody 7E3, 7E3-F(ab')2, directed against the glycoprotein Ilb/Illa (GPIIb/IIIa) receptor of human plate-lets, were studied in groups of four patients with unstable an-gina pectoris. With 0.20 mg/kg, the template bleeding time prolonged from 6.3±1.9 (mean±SD) to> 30 min; it subse-quently decreased to 13±7.8 min after 12 h and to 8.3±1.5 min after 24 h. The number of unblocked GPIIb/IIIa receptors (preinfusion value, 32,000±3,000 per platelet) decreased to 13±7 % of the preinfusion value 1 h after infusion, and the