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p1 progress inourunderstandingof themech-embryonic stem cells (ESCs) (Chen et al., 2008; Kim et al., 2008; Silva et al., 2009). pluripotency transcriptional network. can give rise to multiple transcripts—is known to regulatekeydevelopmental deci-splicing in human ESC pluripotency, Ga-that change as human ESCs differentiate into neural precursor cells, including onesuch as the combination of Oct4, Sox2, Klf4, and c-Myc, are sufficient to repro-gram somatic cells into induced pluripo-tent stem (iPS) cells (Takahashi et al., 2007). These factors appear to activate a transcriptional network that endowscell