Development of Fluorescent Turn-On Sensor for Selective Detection of Cu2+ in Aqueous Solution

Cu2+ is one of the most essential metal ions in biological systems, since it plays an important role in numerous bio-logical processes and can induce various disorders, includ-ing some neurodegenerative diseases such as Alzhemer’s, Prion, and Parkinson’s diseases.1 Thus, quantifying the amount of Cu2+ in a systems crucial for studying the pathological roles of Cu2+ in living systems. The development of fluore-scent sensors for Cu2+ has received much attention in last decade because of their simplicity and high sensitivity.2-6 In addition, fluorescent sensors can offer the potential appli-cation in real time detection in living systems with high spatial resolution that is difficult or impossible to obtain using conventional techniques such as atomic absorption spectroscopy and inductively coupled plasma mass spectro-scopy. In particular, the development of a fluorescent turn-o