doi: 10.1093/ndt/gfs432 Expect the unexpected in the cell therapy of renal ischaemia

stem cells Acute kidney injury (AKI) is a common complication in hospitalized patients associated with incremental increase in short- and long-term mortality [1]. There is a critical unmet medical need to explore new therapeutic ap-proaches for AKI, and cell-based regenerative strategies represent a promising option. Similar to other competitive biomedical research disciplines, the field of experimental nephrology is experiencing a boom in regenerative cellu-lar strategies [2]. One major focus is the induction of tissue regeneration by injection of the different popu-lations of pluripotent stem cells (exogenous or replace-ment strategy). Accordingly, administration of bone marrow-derived haematopoietic, mesenchymal and unse-lected bone marrow-derived cells was extensively studie