Chronic Granulocytic Leukemia (CGL) During the Course of Chronic Lymphocytic Leukemia (CLL): Correlation of Blood, Marrow, and Spleen Morphology and Cytogenetics

Second malignancies occur with a greater described CLL. One patient received total frequency in patients with chronic Iym- body radiation treatment for his CLL, while phatic leukemia than in the general popu- the second was not treated. It is apparent lation. Previously, 20 patients having CLL that previous therapy may not necessarily have been reported as developing acute be a prerequisite for the development of a leukemia, but no cases of development of second malignancy in CLL. Cytogenetics chronic granulocytic leukemia have been offers a useful tool to confirm morphologic observed. In the present report, we will criteria in establishing the diagnosis of a describe patients with Ph ’ chromosome second neoplasm. positive CGL associated with previously S ECOND MALIGNANCIES OCCUR with a greater frequency in patients with chronic lymphocytic leukemia (CLL) than in the general popula-tion.”2 The association of CLL and acute leukemia has been reported in 20 cases.3-8 Each of the 20 patients received cytotoxic or radiation therapy. No cases of chronic granulocytic leukemia (CGL) were observed in these series. W